PRND Gene Summary [Human]
This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRND |
| Official Name | prion like protein doppel [Source:HGNC Symbol;Acc:HGNC:15748] |
| Ensembl ID | ENSG00000171864 |
| Bio databases IDs | |
| Aliases | prion like protein doppel, prion-like protein doppel, downstream prion protein-like gene |
| Synonyms | dJ1068H6.4, DOPPEL, DPL, prion like protein doppel, PrPLP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRND often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prion/Doppel alpha-helical domain
- copper ion binding
- protein binding
- Prion-like protein Doppel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- flagella
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRND gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular copper ion homeostasis
- acrosome reaction
- protein homooligomerization
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding