FIBP Gene Summary [Human]
Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FIBP |
| Official Name | FGF1 intracellular binding protein [Source:HGNC Symbol;Acc:HGNC:3705] |
| Ensembl ID | ENSG00000172500 |
| Bio databases IDs | |
| Aliases | FGF1 intracellular binding protein |
| Synonyms | 2010004G08Rik, 2010005N21Rik, 3010027N18Rik, FGF1 intracellular binding protein, FGF (Acidic) Intracellular Binding, FGFIBP, FIBP-1, fibroblast growth factor (acidic) intracellular binding protein, TROFAS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FIBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibroblast growth factor binding
- Acidic fibroblast growth factor binding (FIBP)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Thauvin-Robinet-Faivre syndrome
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- diffuse cutaneous systemic sclerosis
- Crohn disease
role in cell
- expression in
- phosphorylation in
- proliferation
- G2/M phase
- growth
- formation
- formation in
- quantity
- aggregation
- radiosensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular membranes
- cellular membrane
- Mitochondria
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FIBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast growth factor receptor signaling pathway
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- mitochondrion
- membrane
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- fibroblast growth factor binding