HPSE Gene Summary [Human]
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | HPSE |
| Official Name | heparanase [Source:HGNC Symbol;Acc:HGNC:5164] |
| Ensembl ID | ENSG00000173083 |
| Bio databases IDs | |
| Aliases | heparanase |
| Synonyms | Hep, heparanase, HPA, HPA1, HPR1, HPSE1, HSE1, LOC100362546 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HPSE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-glucuronidase
- heparanase
- enzyme
- protein binding
- syndecan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- non-M3 acute myeloid leukemia
- adenoma formation
- neoplasia
- Crohn disease
- insulin-dependent diabetes mellitus
role in cell
- number
- apoptosis
- expression in
- phosphorylation in
- cell viability
- migration
- invasion by
- proliferation
- activation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear body
- intracellular membrane-bounded organelle
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- intracellular space
- perinuclear region
- membrane surface
- Nucleus
- endosomes
- vesicles
- centrosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- lysosome membrane
- lysosomal compartment
- nucleoplasm
- perinuclear vesicles
- specific granules
- tertiary granules
- extracellular matrix
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HPSE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis involved in wound healing
- positive regulation of osteoblast proliferation
- cell-matrix adhesion
- protein transmembrane transport
- positive regulation of blood coagulation
- vascular wound healing
- proteoglycan metabolic process
- establishment of endothelial barrier
- regulation of hair follicle development
- heparan sulfate proteoglycan catabolic process
- heparin metabolic process
- positive regulation of protein kinase B signaling cascade
- positive regulation of hair follicle development
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- specific granule lumen
- intracellular membrane-bounded organelle
- membrane raft
- lysosomal lumen
- extracellular matrix
- extracellular region
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- heparanase activity
- protein binding
- syndecan binding
- beta-glucuronidase activity