Hpse Gene Summary [Rat]
Enables heparanase activity. Predicted to be involved in several processes, including positive regulation of osteoblast proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and proteoglycan metabolic process. Predicted to be located in lysosome; membrane raft; and nucleoplasm. Predicted to be part of heparanase complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human HPSE (heparanase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpse |
| Official Name | heparanase [Source:RGD Symbol;Acc:61969] |
| Ensembl ID | ENSRNOG00000002188 |
| Bio databases IDs | |
| Aliases | heparanase |
| Synonyms | Hep, heparanase, HPA, HPA1, HPR1, HPSE1, HSE1, LOC100362546 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hpse often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-glucuronidase
- heparanase
- enzyme
- protein binding
- syndecan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- non-M3 acute myeloid leukemia
- adenoma formation
- neoplasia
- Crohn disease
- insulin-dependent diabetes mellitus
role in cell
- number
- apoptosis
- expression in
- phosphorylation in
- cell viability
- migration
- invasion by
- proliferation
- activation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear body
- intracellular membrane-bounded organelle
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- intracellular space
- perinuclear region
- membrane surface
- Nucleus
- endosomes
- vesicles
- centrosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- lysosome membrane
- lysosomal compartment
- nucleoplasm
- perinuclear vesicles
- specific granules
- tertiary granules
- extracellular matrix
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hpse gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis involved in wound healing
- positive regulation of osteoblast proliferation
- cell-matrix adhesion
- protein transmembrane transport
- positive regulation of blood coagulation
- vascular wound healing
- proteoglycan metabolic process
- establishment of endothelial barrier
- regulation of hair follicle development
- heparan sulfate proteoglycan catabolic process
- heparin metabolic process
- positive regulation of protein kinase B signaling cascade
- positive regulation of hair follicle development
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- specific granule lumen
- intracellular membrane-bounded organelle
- membrane raft
- lysosomal lumen
- extracellular matrix
- extracellular region
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- heparanase activity
- protein binding
- syndecan binding
- beta-glucuronidase activity