ADAMTS20 Gene Summary [Human]
The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | ADAMTS20 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif 20 [Source:HGNC Symbol;Acc:HGNC:17178] |
| Ensembl ID | ENSG00000173157 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif 20 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 20, ADAM metallopeptidase with thrombospondin type 1 motif, 20, Adamst20, bt, GON-1, LOC108348285 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAMTS20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- catalytic domain
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- Metallo-peptidase family M12B Reprolysin-like
- GON domain
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the ADAMTS20 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADAMTS20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanocyte differentiation
- signal transduction
- negative regulation of apoptotic process
- proteolysis
- apoptotic process
- extracellular matrix organization
- positive regulation of melanocyte differentiation
- positive regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity