NEK4 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | NEK4 |
| Official Name | NIMA related kinase 4 [Source:HGNC Symbol;Acc:HGNC:11399] |
| Ensembl ID | ENSG00000114904 |
| Bio databases IDs | |
| Aliases | NIMA related kinase 4, serine/threonine protein kinase-2 |
| Synonyms | NIMA (never in mitosis gene a)-related expressed kinase 4, NIMA-related kinase 4, NRK2, pp12301, STK2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- manganese ion binding
- zDHHC ankyrin repeat binding domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- metastasis
- polycystic ovary syndrome
- pervasive developmental disorder
- ciliopathy
regulated by
- monocyte-derived macrophages
- Exendin4
- HGF
role in cell
- expression in
- formation
- formation in
- phosphorylation in
- cell viability
- replicative senescence
- cell cycle progression
- DNA damage response
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ciliary transition zone
- Cytoplasm
- basal bodies
- cytosol
- ciliary rootlet
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- protein phosphorylation
- mitotic cell cycle
- regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- microtubule-based flagellar cytoplasm
- cytoplasm
- cilium basal body
- cytosol
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- ATP binding
- manganese ion binding
- protein serine/threonine kinase activity