Adamts20 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of melanocyte differentiation; and positive regulation of signal transduction. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts20 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 20 [Source:RGD Symbol;Acc:1307725] |
| Ensembl ID | ENSRNOG00000033397 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 20 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 20, ADAM metallopeptidase with thrombospondin type 1 motif, 20, Adamst20, bt, GON-1, LOC108348285 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- catalytic domain
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- Metallo-peptidase family M12B Reprolysin-like
- GON domain
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts20 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- melanocyte differentiation
- signal transduction
- negative regulation of apoptotic process
- proteolysis
- apoptotic process
- extracellular matrix organization
- positive regulation of melanocyte differentiation
- positive regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity