GPR137 Gene Summary [Human]

Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
GPR137
Official Name
G protein-coupled receptor 137 [Source:HGNC Symbol;Acc:HGNC:24300]
Ensembl ID
ENSG00000173264
Bio databases IDs NCBI: 56834 Ensembl: ENSG00000173264
Aliases G protein-coupled receptor 137
Synonyms C11orf4, GPR137A, G protein-coupled receptor 137, LOC684849, TM7SF1L1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR137 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the GPR137 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • plasma cell neoplasm
  • B cell cancer
  • mature B-cell neoplasia
  • organismal death
  • perineural invasion
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • lysosome membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GPR137 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • autophagy
  • negative regulation of osteoclast differentiation
  • regulation of autophagy
  • negative regulation of bone resorption

Cellular Component

Where in the cell the gene product is active
  • lysosomal membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.