DPEP1 Gene Summary [Human]
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
Details
| Type | Protein Coding |
| Official Symbol | DPEP1 |
| Official Name | dipeptidase 1 [Source:HGNC Symbol;Acc:HGNC:3002] |
| Ensembl ID | ENSG00000015413 |
| Bio databases IDs | |
| Aliases | dipeptidase 1 |
| Synonyms | AI327012, DEHYDROPEPTIDASE1, Dipeptidase 1, LOC107984882, MBD, MBD1, MDP, MICROSOMAL DIPEPTIDASE, RDP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPEP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- metalloexopeptidase
- dipeptidase
- peptidase
- caspase inhibitor activity
- membrane dipeptidase
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
- phosphatidylinositol binding
- binding protein
- zinc ion binding
- beta-lactamase
Pathways
Biological processes and signaling networks where the DPEP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ventilator-associated pneumonia
- cancer
- critical illness
- obesity
- infection
- cardiovascular disorder
- cirrhosis
- chronic kidney disease
- bacterial septicemia
- bone and joint infections
role in cell
- proliferation
- expression in
- migration
- polyubiquitination in
- degradation in
- chemotaxis
- recruitment
- oxaliplatin resistance
- irinotecan resistance
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Extracellular Space
- apical compartment
- cellular membrane
- Plasma Membrane
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPEP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antibiotic metabolic process
- glutathione catabolic process
- cellular lactam catabolic process
- inflammatory response
- cellular response to calcium ion
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- glutathione metabolic process
- proteolysis
- cellular response to nitric oxide
- neutrophil chemotaxis
- cellular response to xenobiotic stimulus
- homocysteine metabolic process
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- extracellular space
- extracellular vesicular exosome
- apical part of cell
- cell junction
- apical plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- modified amino acid binding
- zinc ion binding
- protein binding
- metallodipeptidase activity
- dipeptidase activity
- metalloexopeptidase activity
- GPI anchor binding
- beta-lactamase activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process