IPPK Gene Summary [Human]
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | IPPK |
| Official Name | inositol-pentakisphosphate 2-kinase [Source:HGNC Symbol;Acc:HGNC:14645] |
| Ensembl ID | ENSG00000127080 |
| Bio databases IDs | |
| Aliases | inositol-pentakisphosphate 2-kinase |
| Synonyms | 1810043M15Rik, bA476B13.1, C9orf12, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, inositol-pentakisphosphate 2-kinase, InsP5-2K, INSP5 2-KINASE, INSP5K2, InsP6, IP5K, IPK1, RGD1311271, rIpk1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IPPK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-pentakisphosphate 2-kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- SL 327
- levodopa
role in cell
- apoptosis
- organismal death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IPPK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- inositol phosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol pentakisphosphate 2-kinase activity
- protein binding
- binding, bridging