SNX33 Gene Summary [Human]
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | SNX33 |
| Official Name | sorting nexin 33 [Source:HGNC Symbol;Acc:HGNC:28468] |
| Ensembl ID | ENSG00000173548 |
| Bio databases IDs | |
| Aliases | sorting nexin 33 |
| Synonyms | E130307J07Rik, MGC32065, SH3PX3, SH3PXD3C, SNX30, sorting nexin 33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- PX domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial uterine cancer
- cervical cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
regulated by
- MFSD2A
- 3-deazaneplanocin
- geldanamycin
regulates
- F Actin
- APP
role in cell
- apoptosis
- quantity
- growth
- accumulation in
- formation
- tubulation
- cell division
- micronucleation
- organization
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cleavage furrow formation
- negative regulation of endocytosis
- endosome organization
- positive regulation of protein localization at cell surface
- endocytosis
- intracellular protein transport
- membrane tubulation
- negative regulation of protein localization at cell surface
- macropinocytosis
- positive regulation of membrane protein ectodomain proteolysis
- cytokinesis after mitosis
- endosomal transport
- protein import
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- membrane
- cytoplasmic vesicle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- phosphatidylinositol binding