FASLG Gene Summary [Human]
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | FASLG |
| Official Name | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] |
| Ensembl ID | ENSG00000117560 |
| Bio databases IDs | |
| Aliases | Fas ligand |
| Synonyms | ALPS1B, APT1LG1, APTL, CD178, CD95-L, FASL, Fas Ligand, gld, mFasL, Tnfl6, TNFSF6, TNLG1A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FASLG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- death receptor binding
- TNF homology domain
- tumor necrosis factor receptor binding
- TNF
- protein binding
- receptor binding
- cytokine
- proline rich domain
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- Casein kinase I binding site
Pathways
Biological processes and signaling networks where the FASLG gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Apoptosis Signaling
- Aryl Hydrocarbon Receptor Signaling
- CCR5 Signaling in Macrophages
- Corticotropin Releasing Hormone Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Death Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Erythropoietin Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17 Signaling
- Induction of Apoptosis by HIV1
- Myc Mediated Apoptosis Signaling
- Nur77 Signaling in T Lymphocytes
- p38 MAPK Signaling
- PEDF Signaling
- PTEN Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Tec Kinase Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- vascular leak syndrome
- rheumatoid arthritis
- autoimmune disease
- kidney disease
- X-linked immunodeficiency 98 with autoinflammation
- toxic epidermal necrolysis
- splenomegaly
- metastasis
role in cell
- expression in
- cell viability
- apoptosis
- osteoclastogenesis
- accumulation
- activation in
- production
- phosphorylation in
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- lysosome fractions
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- microvesicles
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- intermediate filaments
- plasma membrane extracellular face
- caveolae
- lysosome membrane
- neurites
- cytoplasmic vesicles
- melanosomes
- multivesicular bodies
- membrane rafts
- membrane processes
- perikaryon
- exosomes
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FASLG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- response to growth factor stimulus
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of epidermal growth factor receptor signaling pathway
- apoptotic signaling pathway
- induction of apoptosis via death domain receptors
- positive regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- necroptosis
- endosomal lumen acidification
- apoptotic process
- positive regulation of endothelial cell apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular chloride ion homeostasis
- signal transduction
- retinal cell programmed cell death
- cell-cell signaling
- inflammatory cell apoptotic process
- T cell apoptotic process
- positive regulation of apoptotic process
- response to lipopolysaccharide
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- external side of plasma membrane
- lysosomal lumen
- extracellular region
- plasma membrane
- cytoplasmic membrane-bounded vesicle lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- death receptor binding
- cytokine activity
- receptor binding