CNIH2 Gene Summary [Human]
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | CNIH2 |
| Official Name | cornichon family AMPA receptor auxiliary protein 2 [Source:HGNC Symbol;Acc:HGNC:28744] |
| Ensembl ID | ENSG00000174871 |
| Bio databases IDs | |
| Aliases | cornichon family AMPA receptor auxiliary protein 2 |
| Synonyms | Cnih3, Cnil, cornichon family AMPA receptor auxiliary protein 2, RGD1304930 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNIH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornichon protein
- channel regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- intracellular space
- cellular membrane
- vesicles
- endoplasmic reticulum membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- dendrites
- postsynaptic density
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNIH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- endoplasmic reticulum membrane
- dendrite
- postsynaptic density
- postsynaptic membrane
- dendritic shaft
- ER to Golgi transport vesicle membrane
- dendritic spine
- synapse
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding