GPR171 Gene Summary [Human]
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR171 |
| Official Name | G protein-coupled receptor 171 [Source:HGNC Symbol;Acc:HGNC:30057] |
| Ensembl ID | ENSG00000174946 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 171, platelet activating receptor homolog |
| Synonyms | A630006E05, F730001G15Rik, G protein-coupled receptor 171, H963, LOC681783 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR171 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- neuropeptide binding
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR171 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
role in cell
- proliferation
- accumulation in
- differentiation
- phosphorylation in
- density
- binding
- outgrowth
- outgrowth in
- flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR171 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- negative regulation of myeloid cell differentiation
- G-protein coupled receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- G-protein coupled purinergic nucleotide receptor signaling pathway
- regulation of sensory perception of pain
- regulation of feeding behavior
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- G-protein coupled peptide receptor activity
- neuropeptide receptor activity
- G-protein coupled purinergic nucleotide receptor activity