Gpr171 Gene Summary [Mouse]
Enables neuropeptide binding activity and neuropeptide receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of feeding behavior; and regulation of sensory perception of pain. Acts upstream of or within negative regulation of myeloid cell differentiation. Located in plasma membrane. Orthologous to human GPR171 (G protein-coupled receptor 171). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr171 |
| Official Name | G protein-coupled receptor 171 [Source:MGI Symbol;Acc:MGI:2442043] |
| Ensembl ID | ENSMUSG00000050075 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 171 |
| Synonyms | A630006E05, F730001G15Rik, G protein-coupled receptor 171, H963, LOC681783 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr171 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- neuropeptide binding
- Cholecystokinin A receptor, N-terminal
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr171 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
role in cell
- proliferation
- accumulation in
- differentiation
- phosphorylation in
- density
- binding
- outgrowth
- outgrowth in
- flux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr171 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- negative regulation of myeloid cell differentiation
- G-protein coupled receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- G-protein coupled purinergic nucleotide receptor signaling pathway
- regulation of sensory perception of pain
- regulation of feeding behavior
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- G-protein coupled peptide receptor activity
- neuropeptide receptor activity
- G-protein coupled purinergic nucleotide receptor activity