CTDSP2 Gene Summary [Human]
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CTDSP2 |
| Official Name | CTD small phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:17077] |
| Ensembl ID | ENSG00000175215 |
| Bio databases IDs | |
| Aliases | CTD small phosphatase 2, conserved gene amplified in osteosarcoma, nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, small CTD phosphatase 2 |
| Synonyms | CTD small phosphatase 2, D10ERTD73E, NIF2, OS-4, PSR2, SCP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTDSP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTD phosphatase
- FCP1-like phosphatase, phosphatase domain
- phosphatase
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTDSP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- protein dephosphorylation
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- CTD phosphatase activity
- myosin phosphatase activity