ELL2 Gene Summary [Human]
Involved in snRNA transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ELL2 |
| Official Name | elongation factor for RNA polymerase II 2 [Source:HGNC Symbol;Acc:HGNC:17064] |
| Ensembl ID | ENSG00000118985 |
| Bio databases IDs | |
| Aliases | elongation factor for RNA polymerase II 2, metastatic renal cell carcinoma-associated transcript 1 |
| Synonyms | Ef RNA ii 2, ELL RELATED RNA POLYMERASE II, elongation factor for RNA polymerase II 2, MRCCAT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II elongation factor ELL
- transcription regulator
- protein binding
- Occludin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- coronary artery disease
- septic shock
- psoriasis
- endometriosis
- paraproteinemia
- plasma cell myeloma
- epileptic seizure
- Alzheimer disease
role in cell
- production in
- phosphorylation in
- expression in
- binding in
- association in
- processing in
- transcription in
- alternative splicing in
- elongation in
- exon skipping in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- snRNA transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- core promoter proximal region sequence-specific DNA binding