SNAI1 Gene Summary [Human]
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SNAI1 |
| Official Name | snail family transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:11128] |
| Ensembl ID | ENSG00000124216 |
| Bio databases IDs | |
| Aliases | snail family transcriptional repressor 1 |
| Synonyms | AI194338, dJ710H13.1, SLUGH2, SNA, Sna1, SNAH, SNAIL, SNAIL1, snail family transcriptional repressor 1, snail family zinc finger 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNAI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- 14-3-3 binding domain
- beta-catenin with a destruction motif
- transcription regulator
- GSK3 beta phosphorylation site
- nucleic acid binding
- TrCP binding domain
- SNAG domain
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- kinase binding
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the SNAI1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- acute myeloid leukemia
- advanced cancer
- cancer
- cardiac fibrosis
- renal fibrosis
- breast cancer
- organismal death
- non-small cell lung cancer
role in cell
- apoptosis
- activation in
- proliferation
- phosphorylation in
- migration
- expression in
- growth
- activation
- accumulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- perinuclear space
- centromeres
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNAI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- aortic valve morphogenesis
- palate development
- cartilage morphogenesis
- regulation of transcription, DNA-dependent
- epithelial to mesenchymal transition involved in endocardial cushion formation
- left/right pattern formation
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- positive regulation of transcription, DNA-dependent
- trophoblast giant cell differentiation
- negative regulation of cell differentiation involved in embryonic placenta development
- negative regulation of vitamin D biosynthetic process
- osteoblast differentiation
- hair follicle morphogenesis
- epithelial to mesenchymal transition
- canonical Wnt receptor signaling pathway
- regulation of tight junction assembly
- mesoderm formation
- epithelial cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- centromeric heterochromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- kinase binding
- E-box binding