CHST1 Gene Summary [Human]
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CHST1 |
| Official Name | carbohydrate sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:1969] |
| Ensembl ID | ENSG00000175264 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 1, Keratan sulfotransferase |
| Synonyms | 2610008E20Rik, C6ST, carbohydrate sulfotransferase 1, carbohydrate sulphotransferase 1, GST-1, keratan sulphate gal 6 sulphotransferase, KS6ST, KSGAL6ST, KSST |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHST1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- enzyme
- protein binding
- keratan sulfotransferase
Pathways
Biological processes and signaling networks where the CHST1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- infection by HIV-1
- productive infection by HIV-1
role in cell
- quantity
- binding
- replication in
- cell rolling
- reverse transcription in
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHST1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polysaccharide metabolic process
- keratan sulfate metabolic process
- inflammatory response
- sulfur compound metabolic process
- N-acetylglucosamine metabolic process
- keratan sulfate biosynthetic process
- galactose metabolic process
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- keratan sulfotransferase activity
- protein binding
- N-acetylglucosamine 6-O-sulfotransferase activity
- sulfotransferase activity