MSRA Gene Summary [Human]
This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | MSRA |
| Official Name | methionine sulfoxide reductase A [Source:HGNC Symbol;Acc:HGNC:7377] |
| Ensembl ID | ENSG00000175806 |
| Bio databases IDs | |
| Aliases | methionine sulfoxide reductase A |
| Synonyms | 2310045J23Rik, 6530413P12Rik, methionine sulfoxide reductase A, methionine sulphoxide reductase A, Msrad, Peptide Methionine Sulfoxide Reductase, Peptide Methionine sulphoxide Reductase, PMSR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MSRA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK13014
- enzyme
- protein binding
- protein-methionine-S-oxide reductase
- Peptide methionine sulfoxide reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- inflammatory bowel disease
- Crohn disease
- non-insulin-dependent diabetes mellitus
- esophageal adenocarcinoma
- epithelial cancer
- colorectal cancer
- liver cancer
- schizophrenia
- coronary artery disease
role in cell
- proliferation
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- actin cytoskeleton
- Plasma Membrane
- midbody
- cytosol
- nucleoplasm
- nuclear bodies
- photoreceptor inner segments
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MSRA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein repair
- response to oxidative stress
- protein modification process
- cellular response to oxidative stress
- methionine metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- actin cytoskeleton
- cytosol
- midbody
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide-methionine-(S)-S-oxide reductase activity