TRIM2 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | TRIM2 |
| Official Name | tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974] |
| Ensembl ID | ENSG00000109654 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 2, RING finger protein 86, Charcot-Marie-Tooth disease, type 2R |
| Synonyms | CMT2R, mKIAA0517, narf, RNF86, tripartite motif-containing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Filamin/ABP280 repeat
- B-Box C-terminal domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- WD40
- enzyme
- Ring finger domain
- protein binding
- NHL repeat unit of beta-propeller proteins
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- NHL repeat
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- Filamin-type immunoglobulin domains
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- axonal Charcot-Marie-Tooth disease type 2R
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
- non-insulin-dependent diabetes mellitus
- multiple sclerosis
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- expression in
- apoptosis
- proliferation
- migration
- invasion by
- colony formation by
- degradation in
- neuroprotection in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- regulation of neuron apoptotic process
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- translation repressor activity