CIDEA Gene Summary [Human]
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CIDEA |
| Official Name | cell death inducing DFFA like effector a [Source:HGNC Symbol;Acc:HGNC:1976] |
| Ensembl ID | ENSG00000176194 |
| Bio databases IDs | |
| Aliases | cell death inducing DFFA like effector a |
| Synonyms | cell death-inducing DFFA-like effector a, cell death-inducing DNA fragmentation factor, alpha subunit-like effector A, cell death-inducing DNA fragmentation factor, α subunit-like effector A, Dff, LOC683592 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIDEA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- binding protein
- CIDE-N domain
- protein homodimerization
- CIDE_N
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- adenoma formation
- hepatic steatosis
- aldosterone producing adrenocortical adenoma
- senile lentigo
- obesity
- dry eye
- Ullrich congenital muscular dystrophy
role in cell
- growth
- quantity
- degradation in
- apoptosis
- differentiation
- size
- fusion
- enlargement
- ubiquitination in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- lipid droplet contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIDEA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- regulation of apoptotic process
- negative regulation of execution phase of apoptosis
- lipid metabolic process
- apoptotic process
- temperature homeostasis
- negative regulation of cytokine production
- cellular response to cold
- negative regulation of tumor necrosis factor production
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of lipid catabolic process
- response to stilbenoid
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial envelope
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- phosphatidic acid binding