Cidea Gene Summary [Mouse]
Enables lipid transfer activity; phosphatidic acid binding activity; and protein homodimerization activity. Involved in several processes, including lipid droplet fusion; negative regulation of cold-induced thermogenesis; and regulation of catabolic process. Acts upstream of or within lipid metabolic process. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat and inner ear vestibular component. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cidea |
| Official Name | cell death-inducing DNA fragmentation factor, alpha subunit-like effector A [Source:MGI Symbol;Acc:MGI:1270845] |
| Ensembl ID | ENSMUSG00000024526 |
| Bio databases IDs | |
| Aliases | cell death-inducing DNA fragmentation factor, alpha subunit-like effector A |
| Synonyms | cell death-inducing DFFA-like effector a, cell death-inducing DNA fragmentation factor, alpha subunit-like effector A, cell death-inducing DNA fragmentation factor, α subunit-like effector A, Dff, LOC683592 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cidea often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- binding protein
- CIDE-N domain
- protein homodimerization
- CIDE_N
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- adenoma formation
- hepatic steatosis
- aldosterone producing adrenocortical adenoma
- senile lentigo
- obesity
- dry eye
- Ullrich congenital muscular dystrophy
role in cell
- growth
- quantity
- degradation in
- apoptosis
- differentiation
- size
- fusion
- enlargement
- ubiquitination in
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- lipid droplet contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cidea gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- regulation of apoptotic process
- negative regulation of execution phase of apoptosis
- lipid metabolic process
- apoptotic process
- temperature homeostasis
- negative regulation of cytokine production
- cellular response to cold
- negative regulation of tumor necrosis factor production
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of lipid catabolic process
- response to stilbenoid
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial envelope
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- phosphatidic acid binding