ACAD9 Gene Summary [Human]
This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Details
| Type | Processed Transcript |
| Official Symbol | ACAD9 |
| Official Name | acyl-CoA dehydrogenase family member 9 [Source:HGNC Symbol;Acc:HGNC:21497] |
| Ensembl ID | ENSG00000177646 |
| Bio databases IDs | |
| Aliases | acyl-CoA dehydrogenase family member 9 |
| Synonyms | 2600017P15RIK, 4732402K02, acyl-CoA dehydrogenase family member 9, acyl-CoA dehydrogenase family, member 9, acyl-Coenzyme A dehydrogenase family, member 9, C630012L17RIK, MC1DN20, NPD002, NYGGF2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACAD9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- enzyme
- protein binding
- long-chain-acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACAD9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid metabolic process
- medium-chain fatty acid metabolic process
- mitochondrial respiratory chain complex I assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- mitochondrial membrane
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- acyl-CoA dehydrogenase activity
- protein binding
- medium-chain-acyl-CoA dehydrogenase activity
- flavin adenine dinucleotide binding
- long-chain-acyl-CoA dehydrogenase activity