SIRT3 Gene Summary [Human]
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Details
| Type | Protein Coding |
| Official Symbol | SIRT3 |
| Official Name | sirtuin 3 [Source:HGNC Symbol;Acc:HGNC:14931] |
| Ensembl ID | ENSG00000142082 |
| Bio databases IDs | |
| Aliases | sirtuin 3 |
| Synonyms | 2310003L23Rik, SIR2L3, Sirtuin 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein deacetylase activity
- zinc ion binding
- catalytic domain
- enzyme binding
- enzyme
- protein binding
- sequence-specific DNA binding
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the SIRT3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- neoplasia
- chronic lymphocytic leukemia
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- obesity
- metabolic syndrome X
- proteinuria
- fibrosis
- Alzheimer disease
role in cell
- proliferation
- phosphorylation in
- accumulation in
- expression in
- production in
- cell death
- molecular cleavage in
- apoptosis
- oligomerization in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- inner membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of ERK1 and ERK2 cascade
- protein deacetylation
- peptidyl-lysine deacetylation
- positive regulation of insulin secretion
- aerobic respiration
- positive regulation of ceramide biosynthetic process
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- NAD-dependent protein deacetylase activity
- protein binding
- sequence-specific DNA binding
- NAD-dependent histone deacetylase activity
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity
- enzyme binding