EIF3K Gene Summary [Human]
The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | EIF3K |
| Official Name | eukaryotic translation initiation factor 3 subunit K [Source:HGNC Symbol;Acc:HGNC:24656] |
| Ensembl ID | ENSG00000178982 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit K |
| Synonyms | 1200009C21RIK, ARG134, EIF3-p28, EIF3S12, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 subunit K, eukaryotic translation initiation factor 3, subunit K, HSPC029, M9, MSTP001, PLAC-24, PRO1474, PTD001 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3K often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAC3/GANP family
- translation initiation factor
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF3K gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3K gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- eukaryotic 43S preinitiation complex
- membrane
- cytosol
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding
- ribosome binding