MRFAP1 Gene Summary [Human]
This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | MRFAP1 |
| Official Name | Morf4 family associated protein 1 [Source:HGNC Symbol;Acc:HGNC:24549] |
| Ensembl ID | ENSG00000179010 |
| Bio databases IDs | |
| Aliases | Morf4 family associated protein 1 |
| Synonyms | Morf4 family associated protein 1, PAM14, PGR1, RGD1306635 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRFAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- MORF4 family-associated protein1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- perinuclear region
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRFAP1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding