MORF4L1 Gene Summary [Human]
Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MORF4L1 |
| Official Name | mortality factor 4 like 1 [Source:HGNC Symbol;Acc:HGNC:16989] |
| Ensembl ID | ENSG00000185787 |
| Bio databases IDs | |
| Aliases | mortality factor 4 like 1, MORF-related gene on chromosome 15, Esa1p-associated factor 3 homolog (S. cerevisiae) |
| Synonyms | Eaf3, FWP006, HsT17725, MEAF3, mKIAA4002, MORFRG15, mortality factor 4 like 1, MRG15, S863-6, TEG-189, Tex189 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MORF4L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- leucine zipper domain
- chromatin binding
- protein binding
- helix-loop-helix domain
- MRG
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- heart disease
- cardiovascular disorder
- myocardial infarction
- respiratory failure
- cardiac hypertrophy
- coronary artery disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung carcinoma process
role in cell
- proliferation
- quantity
- cell cycle progression
- size
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- perinuclear region
- nucleosomes
- nucleoplasm
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MORF4L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of double-strand break repair
- double-strand break repair via homologous recombination
- regulation of apoptotic process
- regulation of cell cycle
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- nuclear speck
- nucleosome
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding