PRAP1 Gene Summary [Human]
Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PRAP1 |
| Official Name | proline rich acidic protein 1 [Source:HGNC Symbol;Acc:HGNC:23304] |
| Ensembl ID | ENSG00000165828 |
| Bio databases IDs | |
| Aliases | proline rich acidic protein 1 |
| Synonyms | PRO1195, proline-rich acidic protein 1, UPA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Proline-rich acidic protein 1, pregnancy-specific uterine
- growth factor domain
- uPAR binding domain
- protein binding
- triglyceride binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- weight gain
role in cell
- expression in
- chemotaxis
- apoptosis
- migration
- cell death
- synthesis in
- differentiation
- cell cycle progression
- DNA damage response
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- Extracellular Space
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- cellular response to X-ray
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of apoptotic process
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- triglyceride binding
- protein binding