TXN2 Gene Summary [Human]
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TXN2 |
| Official Name | thioredoxin 2 [Source:HGNC Symbol;Acc:HGNC:17772] |
| Ensembl ID | ENSG00000100348 |
| Bio databases IDs | |
| Aliases | thioredoxin 2 |
| Synonyms | 2510006J11Rik, COXPD29, MTRX, MT-TRX, thioredoxin 2, TRX2, TXN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TXN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- thioredoxin-like domain
- catalytic domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- sulfur group:disulfide oxidoreductase
- enzyme
- protein binding
- protein-methionine-S-oxide reductase
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- hypertension
- combined oxidative phosphorylation deficiency 29
role in cell
- cell death
- apoptosis
- proliferation
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- mitochondrial matrix
- nucleoli
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TXN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- response to glucose stimulus
- response to hypoxia
- cellular response to nutrient levels
- cell redox homeostasis
- response to axon injury
- response to organic cyclic compound
- response to xenobiotic stimulus
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- dendrite
- mitochondrial matrix
- mitochondrion
- neuronal cell body
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein disulfide oxidoreductase activity
- protein binding
- peptide-methionine-(S)-S-oxide reductase activity
- peptide-methionine (R)-S-oxide reductase activity