TRIML2 Gene Summary [Human]
This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | TRIML2 |
| Official Name | tripartite motif family like 2 [Source:HGNC Symbol;Acc:HGNC:26378] |
| Ensembl ID | ENSG00000179046 |
| Bio databases IDs | |
| Aliases | tripartite motif family like 2, SPRY domain containing 6 |
| Synonyms | EG622117, LOC682851, RGD1565382, SPRYD6, tripartite motif family-like 2, Tu4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIML2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- SPRY domain
- protein binding
- identical protein binding
- associated with SPRY domains
- SPRY-associated domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIML2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- innate immune response
- regulation of gene expression
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding