SUMO2 Gene Summary [Human]
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SUMO2 |
| Official Name | small ubiquitin like modifier 2 [Source:HGNC Symbol;Acc:HGNC:11125] |
| Ensembl ID | ENSG00000188612 |
| Bio databases IDs | |
| Aliases | small ubiquitin like modifier 2 |
| Synonyms | HSMT3, small ubiquitin-like modifier 2, Smt3A, SMT3B, SMT3H2, SUMO3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUMO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- ubiquitin protein ligase binding
- SUMO transferase activity
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- enzyme
- retinoid X receptor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- aortic valve calcification
- growth failure
- infection by Listeria monocytogenes
- infection by HIV-1
role in cell
- expression in
- apoptosis
- proliferation
- morphology
- differentiation
- dissociation
- replication in
- degradation in
- binding in
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- midbody
- sister chromatids
- nucleoplasm
- nucleoli
- nuclear bodies
- XY bodies
- nuclear speckles
- synapse
- PML nuclear bodies
- centromeres
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUMO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- RNA binding
- small conjugating protein ligase binding
- protein tag