FOXM1 Gene Summary [Human]
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Details
| Type | Retained Intron |
| Official Symbol | FOXM1 |
| Official Name | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] |
| Ensembl ID | ENSG00000111206 |
| Bio databases IDs | |
| Aliases | forkhead box M1, M-phase phosphoprotein 2 |
| Synonyms | AA408308, BB238854, D1Mgi56, Fkh16, FKHL16, FOCM1, forkhead box M1, FOXM1B, HFH-11, HFH-11B, HNF-3, INS-1, MPHOSPH2, MPM2, MPP-2, PIG29, TRIDENT, WIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein kinase binding
- FH_FOX
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- KEN box
- phosphorylation site
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- destruction box
- double-stranded DNA binding
- E7 binding domain
- cyclin-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the FOXM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- cardiac fibrosis
- gastric cancer
- neoplasia
- obesity
- neoplastic cell transformation
- chromosomal instability
- non-small cell lung cancer
- cardiac hypertrophy
role in cell
- expression in
- cell viability
- inhibition
- morphology
- apoptosis
- growth
- transcription in
- cell cycle progression
- accumulation
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of cell proliferation
- regulation of Ras protein signal transduction
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- negative regulation of transcription from RNA polymerase II promoter
- G2/M transition of mitotic cell cycle
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of reactive oxygen species metabolic process
- negative regulation of stress-activated MAPK cascade
- regulation of cell cycle
- positive regulation of double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity