SGPP2 Gene Summary [Human]
The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | SGPP2 |
| Official Name | sphingosine-1-phosphate phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:19953] |
| Ensembl ID | ENSG00000163082 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate phosphatase 2 |
| Synonyms | RGD1565739, Sph1PP, sphingosine-1-phosphate phosphatase 2, SPP2, SPPase2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGPP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- phosphatase
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- ulcerative colitis
- dextran sodium sulfate-induced colitis
- Tourette syndrome
- anorexia nervosa
role in cell
- function
- apoptosis
- expression in
- activation in
- proliferation
- growth
- mass
- infiltration by
- growth in
- paracellular permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGPP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- sphingosine metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate phosphatase activity
- dihydrosphingosine-1-phosphate phosphatase activity