APOBEC3G Gene Summary [Human]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]
Details
| Type | Retained Intron |
| Official Symbol | APOBEC3G |
| Official Name | apolipoprotein B mRNA editing enzyme catalytic subunit 3G [Source:HGNC Symbol;Acc:HGNC:17357] |
| Ensembl ID | ENSG00000239713 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme catalytic subunit 3G, DNA dC->dU-editing enzyme APOBEC-3G |
| Synonyms | A3G, apolipoprotein B mRNA editing enzyme catalytic subunit 3G, ARCD, ARP-9, bK150C2.7, CEM-15, dJ494G10.1, MDS019 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOBEC3G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- APOBEC-like N-terminal domain
- dCTP deaminase
- enzyme
- protein binding
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- identical protein binding
- Secreted Novel AID/APOBEC-like Deaminase 4
- RNA binding
- APOBEC3
- zinc ion binding
- cytidine deaminase
- Novel AID APOBEC clade 2
- active site
- Novel AID APOBEC clade 1
- APOBEC4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- breast cancer
- acute myeloid leukemia
- polyglandular autoimmune syndrome type 1
regulates
- cytosine
- APOBEC3G
- GAG
- VIF
- deoxyuridine
- deoxycytidine
- cytidine
- genomic DNA
role in cell
- production in
- stabilization in
- mutagenesis in
- integration in
- replication in
- formation in
- synthesis in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cytoplasmic mRNA processing body
- Cytoplasm
- cytoplasmic aggregates
- cytosol
- late endosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOBEC3G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA cytosine deamination
- negative regulation of retroviral genome replication
- negative regulation of transposition, RNA-mediated
- innate immune response
- defense response to virus
- negative regulation of viral reproduction
- cytidine deamination
- positive regulation of defense response to virus by host
- base conversion or substitution editing
- negative regulation of viral genome replication
- cytidine to uridine editing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- apolipoprotein B mRNA editing enzyme complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- RNA binding
- protein binding
- dCTP deaminase activity
- cytidine deaminase activity