SUGT1 Gene Summary [Human]

This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

Details

Type
Processed Transcript
Official Symbol
SUGT1
Official Name
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [Source:HGNC Symbol;Acc:HGNC:16987]
Ensembl ID
ENSG00000165416
Bio databases IDs NCBI: 10910 Ensembl: ENSG00000165416
Aliases SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Synonyms 2410174K12RIK, Aa1114, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone, SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUGT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • CS domain
  • SGS domain
  • alpha-crystallin Hsps/p23-like
  • Tetratricopeptide repeats
  • protein binding
  • tetratricopeptide repeat
  • RNA binding

Pathways

Biological processes and signaling networks where the SUGT1 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • androgenic alopecia
  • Alzheimer disease
regulated by
regulates
role in cell
  • colony formation
  • cell viability
  • organization
  • proliferation by
  • destabilization in
  • assembly
  • misalignment in
  • misalignment

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytosol
  • nuclear bodies
  • kinetochores

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SUGT1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spindle organization
  • regulation of protein stability
  • kinetochore assembly
  • satellite cell proliferation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • ubiquitin ligase complex
  • cytosol
  • macromolecular complex
  • kinetochore

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • chaperone binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.