SLC26A11 Gene Summary [Human]
This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SLC26A11 |
| Official Name | solute carrier family 26 member 11 [Source:HGNC Symbol;Acc:HGNC:14471] |
| Ensembl ID | ENSG00000181045 |
| Bio databases IDs | |
| Aliases | solute carrier family 26 member 11 |
| Synonyms | F630021I08RIK, KBAT, LOC688294, MGC46523, solute carrier family 26 member 11, solute carrier family 26, member 11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC26A11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sulfate permease family
- sulfate transporter
- high affinity sulphate transporter 1
- protein binding
- chloride transporter
- bicarbonate transporter
- sulphate transporter and anti-sigma factor antagonist domain
- anion transporter
- PRK11660
- chloride channel
- antiporter
- inorganic anion exchanger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- apical membrane
- basolateral membrane
- lysosome membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC26A11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- ion transport
- oxalate transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- Golgi apparatus
- basolateral plasma membrane
- lysosomal membrane
- apical plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- secondary active sulfate transmembrane transporter activity
- protein binding
- anion transmembrane transporter activity
- chloride channel activity
- sulfate transmembrane transporter activity