C5AR2 Gene Summary [Human]
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | C5AR2 |
| Official Name | complement component 5a receptor 2 [Source:HGNC Symbol;Acc:HGNC:4527] |
| Ensembl ID | ENSG00000134830 |
| Bio databases IDs | |
| Aliases | complement component 5a receptor 2, complement C5a receptor 2 |
| Synonyms | C5L2, complement C5a receptor 2, complement component 5a receptor 2, E030029A11RIK, GPF77, GPR77 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C5AR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- serine threonine rich domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the C5AR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute septic peritonitis
- airway hyperresponsiveness
- multiple system atrophy
- multiple organ failure
- sepsis
- lymphopenia
- edema
- epidermolysis bullosa acquisita
- pathogenesis
role in cell
- quantity
- molecular cleavage in
- activation
- migration
- presence
- formation
- chemotaxis
- degranulation
- number
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- apical compartment
- cellular membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C5AR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- chemotaxis
- inflammatory response
- negative regulation of neutrophil chemotaxis
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- negative regulation of tumor necrosis factor production
- regulation of interleukin-8 production
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- apical part of cell
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- complement component C5a receptor activity
- protein binding