ADO Gene Summary [Human]
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADO |
| Official Name | 2-aminoethanethiol dioxygenase [Source:HGNC Symbol;Acc:HGNC:23506] |
| Ensembl ID | ENSG00000181915 |
| Bio databases IDs | |
| Aliases | 2-aminoethanethiol dioxygenase, cysteamine dioxygenase |
| Synonyms | 2-aminoethanethiol dioxygenase, C10orf22, FLJ14547, Gm237, RGD1308233 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- iron ion binding
- enzyme
- protein binding
- cysteamine dioxygenase
- RmlC-like cupin superfamily
- PCO_ADO
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- cysteamine dioxygenase activity