TMIGD1 Gene Summary [Human]
Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMIGD1 |
| Official Name | transmembrane and immunoglobulin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:32431] |
| Ensembl ID | ENSG00000182271 |
| Bio databases IDs | |
| Aliases | transmembrane and immunoglobulin domain containing 1 |
| Synonyms | 2010002A20Rik, RGD1307444, TMIGD, transmembrane and immunoglobulin domain containing 1, UNQ9372 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMIGD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD19_double_Ig
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein homodimerization
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Mitochondria
- cytosol
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMIGD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intestinal epithelial cell maturation
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- protein localization
- cellular response to hydroperoxide
- response to nutrient
- regulation of cell migration
- cell migration
- regulation of cell proliferation
- cell-cell junction organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding