Tmigd1 Gene Summary [Rat]
Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Predicted to be involved in several processes, including cell-cell adhesion; negative regulation of apoptotic process; and regulation of membrane permeability. Predicted to act upstream of or within several processes, including brush border assembly; cellular response to hydroperoxide; and intestinal epithelial cell maturation. Predicted to be located in cytosol; mitochondrion; and plasma membrane. Predicted to be active in cell surface. Orthologous to human TMIGD1 (transmembrane and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmigd1 |
| Official Name | transmembrane and immunoglobulin domain containing 1 [Source:RGD Symbol;Acc:1307444] |
| Ensembl ID | ENSRNOG00000003865 |
| Bio databases IDs | |
| Aliases | transmembrane and immunoglobulin domain containing 1 |
| Synonyms | 2010002A20Rik, RGD1307444, TMIGD, transmembrane and immunoglobulin domain containing 1, UNQ9372 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmigd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD19_double_Ig
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein homodimerization
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Mitochondria
- cytosol
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmigd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intestinal epithelial cell maturation
- negative regulation of apoptotic process
- negative regulation of epithelial cell proliferation
- protein localization
- cellular response to hydroperoxide
- response to nutrient
- regulation of cell migration
- cell migration
- regulation of cell proliferation
- cell-cell junction organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- neuron projection
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding