CLEC4G Gene Summary [Human]
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
Details
| Type | Protein Coding |
| Official Symbol | CLEC4G |
| Official Name | C-type lectin domain family 4 member G [Source:HGNC Symbol;Acc:HGNC:24591] |
| Ensembl ID | ENSG00000182566 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4 member G |
| Synonyms | 4930572L20RIK, C-type lectin domain family 4 member G, C-type lectin domain family 4, member G, DTTR431, LP2698, LSECTIN, RGD1562320, UNQ431 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC4G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- monosaccharide binding
- binding protein
- viral receptor
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- Lectin C-type domain
- protein binding
- polysaccharide binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- dextran sodium sulfate-induced colitis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- angioimmunoblastic T-cell lymphoma
- thrombocytopenia
- infection by adenoviridae
role in cell
- expression in
- proliferation
- production in
- binding
- phagocytosis
- phagocytosis by
- number
- downregulation in
- activity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC4G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- T cell mediated immunity
- negative regulation of T cell mediated immunity
- immune response
- interspecies interaction between organisms
- negative regulation of immature T cell proliferation in thymus
- alpha-beta T cell proliferation
- negative regulation of alpha-beta T cell proliferation
- immature T cell proliferation in thymus
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- fructose binding
- mannose binding
- protein binding
- viral receptor activity
- carbohydrate binding
- polysaccharide binding