TNFAIP3 Gene Summary [Human]
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | TNFAIP3 |
| Official Name | TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] |
| Ensembl ID | ENSG00000118503 |
| Bio databases IDs | |
| Aliases | TNF alpha induced protein 3 |
| Synonyms | A20, AIFBL1, AISBL, MAD6, OTUD7C, TNFA1P2, TNF alpha-INDUCED protein 3, TNF-inducible early response, Tnfip3, TNF α-INDUCED protein 3, tumor necrosis factor, alpha-induced protein 3, tumor necrosis factor, α-induced protein 3, tumour necrosis factor, alpha-induced protein 3, tumour necrosis factor, α-induced protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFAIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- catalytic domain
- ubiquitin binding
- A20-like zinc finger
- enzyme
- protein binding
- identical protein binding
- ovarian tumor domain
- protease domain
- kinase binding
- ubiquitin-protein transferase activity
- ubiquitin-specific protease
- zinc finger domain
- OTU-like cysteine protease
- deubiquitinating catalytic domain
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the TNFAIP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- eczema
- glioma formation
- skin cancer
- neoplastic cell transformation
- psoriasis
- Behcet-like familial autoinflammatory syndrome
- paroxysmal nocturnal hemoglobinuria
- organismal death
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- quantity
- binding in
- activation in
- activation
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFAIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- response to muramyl dipeptide
- negative regulation of interleukin-1 beta production
- negative regulation of osteoclast proliferation
- inflammatory response
- response to molecule of bacterial origin
- negative regulation of chronic inflammatory response
- regulation of germinal center formation
- apoptotic process
- negative regulation of toll-like receptor 5 signaling pathway
- establishment of protein localization to vacuole
- negative regulation of endothelial cell apoptotic process
- negative regulation of protein ubiquitination
- negative regulation of tumor necrosis factor production
- negative regulation of toll-like receptor 3 signaling pathway
- protein K11-linked deubiquitination
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of toll-like receptor 4 signaling pathway
- regulation of vascular wound healing
- negative regulation of inflammatory response
- positive regulation of protein catabolic process
- negative regulation of bone resorption
- negative regulation of interleukin-6 production
- tolerance induction to lipopolysaccharide
- negative regulation of toll-like receptor 2 signaling pathway
- positive regulation of Wnt receptor signaling pathway
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of innate immune response
- negative regulation of interleukin-2 production
- B-1 B cell homeostasis
- regulation of defense response to virus by host
- negative regulation of smooth muscle cell proliferation
- cellular response to hydrogen peroxide
- cell migration
- protein deubiquitination
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- negative regulation of CD40 signaling pathway
- cellular response to lipopolysaccharide
- regulation of tumor necrosis factor-mediated signaling pathway
- proteolysis
- negative regulation of B cell activation
- positive regulation of hepatocyte proliferation
- protein K29-linked deubiquitination
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- ubiquitin-protein ligase activity
- DNA binding
- zinc ion binding
- identical protein binding
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding
- protease binding
- kinase binding