HS3ST4
HS3ST4 Gene Summary
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HS3ST4 |
| Official Name | heparan sulfate-glucosamine 3-sulfotransferase 4 [Source:HGNC Symbol;Acc:HGNC:5200] |
| Ensembl ID | ENSG00000182601 |
| Bio databases IDs | |
| Aliases | heparan sulfate-glucosamine 3-sulfotransferase 4 |
| Synonyms | 30ST4,3-OST-4,Gm6915,h3-OST-4,heparan sulfate (glucosamine) 3-O-sulfotransferase 4,heparan sulfate-glucosamine 3-sulfotransferase 4,heparan sulphate (glucosamine) 3-O-sulphotransferase 4,heparan sulphate-glucosamine 3-sulphotransferase 4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- [heparan sulfate]-glucosamine 3-sulfotransferase 1
- Sulfotransferase domain
- enzyme
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the HS3ST4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- INTS7
- HS3ST2
- IPO13
- PPP4R3B
- AIDA
- ELMO2
- DOCK4
- DOCK3
- HS6ST3
- TBC1D24
disease
- acute myeloid leukemia
- age-related macular degeneration
- schizophrenia
- eosinophilic esophagitis
regulated by
- TSHZ3
- TERF2
- ARID1A
regulates
- heparan sulfate proteoglycan
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HS3ST4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process
- heparan sulfate proteoglycan metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- Golgi membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity