EPHA10 Gene Summary [Human]
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | EPHA10 |
| Official Name | EPH receptor A10 [Source:HGNC Symbol;Acc:HGNC:19987] |
| Ensembl ID | ENSG00000183317 |
| Bio databases IDs | |
| Aliases | EPH receptor A10 |
| Synonyms | A330090H18, DFNA88, EPH receptor A10, LOC100504449, LOC100504633, RGD1562679 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EPHA10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- transmembrane-ephrin receptor
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the EPHA10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EPHA10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ephrin receptor signaling pathway
- axon guidance
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane-ephrin receptor activity