BANP Gene Summary [Human]
This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Details
| Type | Processed Transcript |
| Official Symbol | BANP |
| Official Name | BTG3 associated nuclear protein [Source:HGNC Symbol;Acc:HGNC:13450] |
| Ensembl ID | ENSG00000172530 |
| Bio databases IDs | |
| Aliases | BTG3 associated nuclear protein, BEN domain containing 1 |
| Synonyms | BANP HOMOLOG, BEND1, BTG3 associated nuclear protein, SMAR, SMAR1, SMARBP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BANP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The BEN domain is found in diverse animal proteins
- BEN domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- colorectal cancer
- metabolic syndrome X
- necrotizing enterocolitis
- frontal fibrosing alopecia
role in cell
- proliferation
- migration
- activation in
- expression in
- apoptosis
- epithelial-mesenchymal transition
- recruitment in
- binding in
- ubiquitination in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BANP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- chromatin organization
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding