MRGPRX2 Gene Summary [Human]
Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MRGPRX2 |
| Official Name | MAS related GPR family member X2 [Source:HGNC Symbol;Acc:HGNC:17983] |
| Ensembl ID | ENSG00000183695 |
| Bio databases IDs | |
| Aliases | MAS related GPR family member X2 |
| Synonyms | MAS related GPR family member X2, MGRG3, MRGX2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRGPRX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide binding
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- cancer
- systemic mastocytosis
- colon cancer
role in cell
- chemotaxis
- activation
- production in
- degranulation
- degranulation in
- mobilization in
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRGPRX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- sensory perception of pain
- sleep
- mast cell activation
- mast cell degranulation
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding