NPFF Gene Summary [Human]
This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | NPFF |
| Official Name | neuropeptide FF-amide peptide precursor [Source:HGNC Symbol;Acc:HGNC:7901] |
| Ensembl ID | ENSG00000139574 |
| Bio databases IDs | |
| Aliases | neuropeptide FF-amide peptide precursor |
| Synonyms | FMRFAL, neuropeptide FF-amide peptide precursor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPFF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- receptor agonist activity
- protein binding
- receptor binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- repetitive behavior
- sneeze
role in cell
- activation
- production
- hyperexcitability
- elevation in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- vesicles
- secretory granules
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPFF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- neuropeptide signaling pathway
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- perikaryon
- extracellular region
- axon terminus
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- neuropeptide hormone activity
- receptor binding