TAC1 Gene Summary [Human]
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | TAC1 |
| Official Name | tachykinin precursor 1 [Source:HGNC Symbol;Acc:HGNC:11517] |
| Ensembl ID | ENSG00000006128 |
| Bio databases IDs | |
| Aliases | tachykinin precursor 1, substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma, preprotachykinin, protachykinin |
| Synonyms | 4930528L02Rik, B-ppt, Hs.2563, NEUROPEPTIDE gamma, NEUROPEPTIDE K, NEUROPEPTIDE γ, NK-1, NK2, NKA, NKNA, NPK, Ppt5fl, PPT-A, PPTA3, PPT-I, RATPPTA3, Substance P precursor, TAC, TAC2, Tachykinin, tachykinin 1, Tachykinin A, tachykinin precursor 1, tachykinin, precursor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lumenal domain
- G-protein-coupled receptor binding
- transmembrane domain
- receptor agonist activity
- protein binding
Pathways
Biological processes and signaling networks where the TAC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- Parkinson disease
- pain
- psoriasis
- Huntington disease
- schizophrenia
- edema
- essential hypertension
- weight loss
- urinary incontinence
role in cell
- expression in
- phosphorylation in
- production in
- activation
- activation in
- loss
- adhesion
- cell death
- chemotaxis
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- granules
- synaptic vesicles
- nerve ending
- dense-core vesicles
- secretory granules
- extracellular matrix
- perikaryon
- axons
- dendrites
- axon terminals
- plasma
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to pain
- neuropeptide signaling pathway
- inflammatory response
- detection of abiotic stimulus
- cell-cell signaling
- synaptic transmission
- sensory perception of pain
- insemination
- tachykinin receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- synapse
- neuronal cell body
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- substance P receptor binding