TRIM52 Gene Summary [Human]
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | TRIM52 |
| Official Name | tripartite motif containing 52 [Source:HGNC Symbol;Acc:HGNC:19024] |
| Ensembl ID | ENSG00000183718 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 52 |
| Synonyms | RNF102, tripartite motif containing 52 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- transcription co-activator
- ubiquitin protein ligase activity
- B-box zinc finger
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- defense response to virus
- positive regulation of NF-kappaB transcription factor activity
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- transcription coactivator activity